Lucia Manzoli Selected Research

Phospholipase C beta

8/2023	Emerging Roles of Phospholipase C Beta Isozymes as Potential Biomarkers in Cardiac Disorders.
1/2023	Advances in MDS/AML and inositide signalling.
11/2020	Phospholipase C beta1 (PI-PLCbeta1)/Cyclin D3/protein kinase C (PKC) alpha signaling modulation during iron-induced oxidative stress in myelodysplastic syndromes (MDS).
1/2020	Glycogen Synthase Kinase-3 and phospholipase C-beta signalling: Roles and possible interactions in myelodysplastic syndromes and acute myeloid leukemia.
1/2007	Nuclear inositide signaling: an appraisal of phospholipase C beta 1 behavior in myelodysplastic and leukemia cells.
1/2005	Nuclear phospholipase C beta1, regulation of the cell cycle and progression of acute myeloid leukemia.
5/2002	Nuclear PLCbeta(1) acts as a negative regulator of p45/NF-E2 expression levels in Friend erythroleukemia cells.

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Lucia Manzoli Research Topics

Disease

16	Neoplasms (Cancer) 01/2023 - 01/2002
13	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/2024 - 02/2009
9	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2023 - 01/2005
7	Leukemia 01/2023 - 02/2005
5	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2023 - 01/2021
3	Glioma (Gliomas) 01/2023 - 01/2019
3	Acute Erythroblastic Leukemia (Erythroleukemia) 09/2017 - 05/2002
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2022 - 01/2021
2	Myotonic Dystrophy (Dystrophia Myotonica) 01/2017 - 01/2016
1	Cardiomegaly (Heart Hypertrophy) 08/2023
1	Reperfusion Injury 08/2023
1	Heart Diseases (Heart Disease) 08/2023
1	Diabetic Cardiomyopathies 08/2023
1	Myocardial Ischemia (Ischemic Heart Diseases) 08/2023
1	Cardiovascular Diseases (Cardiovascular Disease) 08/2023
1	Brain Neoplasms (Brain Tumor) 01/2023
1	Pancreatic Neoplasms (Pancreatic Cancer) 01/2023
1	Parkinson Disease (Parkinson's Disease) 01/2023
1	Inborn Genetic Diseases (Disease, Hereditary) 08/2022
1	Wounds and Injuries (Trauma) 05/2022
1	Glioblastoma (Glioblastoma Multiforme) 03/2022
1	Laminopathies 02/2022
1	Brain Diseases (Brain Disorder) 02/2022
1	Arteriovenous Fistula 01/2022
1	Inflammation (Inflammations) 01/2022
1	Hypoxia (Hypoxemia) 01/2021
1	Breast Neoplasms (Breast Cancer) 12/2020
1	Radicular Cyst 02/2019
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 03/2018
1	Infertility (Sterility) 01/2017
1	Disease Progression 01/2014
1	Genomic Instability 01/2014
1	Hematologic Neoplasms (Hematological Malignancy) 07/2012
1	Carcinogenesis 08/2006

Drug/Important Bio-Agent (IBA)

7	Phospholipase C betaIBA 08/2023 - 05/2002
6	Protein Isoforms (Isoforms)IBA 08/2023 - 11/2014
5	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2024 - 04/2020
5	EnzymesIBA 08/2022 - 06/2016
4	IsoenzymesIBA 08/2023 - 01/2002
4	Type C PhospholipasesIBA 01/2023 - 05/2002
4	Lamin Type B (Lamin B)IBA 01/2023 - 01/2021
3	LipidsIBA 01/2023 - 10/2002
3	Azacitidine (5 Azacytidine)FDA Link 01/2023 - 06/2013
3	Cyclin D3IBA 11/2020 - 01/2016
2	Phospholipids (Phosphatides)FDA LinkGeneric 08/2023 - 04/2020
2	DiglyceridesIBA 01/2023 - 07/2020
2	Phosphotransferases (Kinase)IBA 07/2020 - 07/2012
2	phosphatidylinositol 3,4,5-triphosphateIBA 04/2020 - 08/2006
2	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 03/2018 - 02/2005
2	Reactive Oxygen Species (Oxygen Radicals)IBA 04/2015 - 01/2014
1	CytokinesIBA 01/2024
1	Biomarkers (Surrogate Marker)IBA 08/2023
1	Phospholipases (Phospholipase)IBA 01/2023
1	lysophosphatidic acidIBA 01/2023
1	Lenalidomide (CC 5013)FDA Link 01/2023
1	Antimalarials (Antimalarial Agents)IBA 01/2023
1	Chloroquine (Aralen)FDA LinkGeneric 01/2023
1	MicroRNAs (MicroRNA)IBA 01/2023
1	Hydroxychloroquine (Plaquenil)FDA LinkGeneric 01/2023
1	Phosphatidic Acids (Phosphatidic Acid)IBA 01/2023
1	Arachidonic Acid (Vitamin F)IBA 01/2023
1	Thymidine PhosphorylaseIBA 08/2022
1	LaminsIBA 02/2022
1	roxadustatIBA 01/2021
1	HematinicsIBA 01/2021
1	Phosphatidylinositol PhosphatesIBA 01/2021
1	Daunorubicin (Cerubidine)FDA LinkGeneric 12/2020
1	Doxorubicin (Adriamycin)FDA LinkGeneric 12/2020
1	epidermal growth factor receptor VIIIIBA 12/2020
1	IronIBA 11/2020
1	Protein Kinase CIBA 11/2020
1	rho GTP-Binding Proteins (rho GTP-Binding Protein)IBA 07/2020
1	Phosphatidylinositol 4,5-Diphosphate (Phosphatidylinositol 4,5 Diphosphate)IBA 04/2020
1	Glycogen Synthase (Synthase I)IBA 01/2020
1	MineralsIBA 02/2019
1	EndocannabinoidsIBA 01/2019
1	Dexamethasone (Maxidex)FDA LinkGeneric 03/2018
1	GlucocorticoidsIBA 03/2018
1	Cyclin B1IBA 11/2014
1	NADPH Oxidases (NAD(P)H oxidase)IBA 01/2014
1	ElementsIBA 01/2014
1	Erythropoietin FDA Link 06/2013
1	Metformin (Glucophage)FDA LinkGeneric 07/2012
1	AMP-Activated Protein KinasesIBA 07/2012
1	DiamideIBA 07/2012
1	AICA ribonucleotide (ZMP)IBA 07/2012
1	TOR Serine-Threonine KinasesIBA 09/2009
1	Phosphoinositide Phospholipase CIBA 02/2009
1	Arsenic Trioxide (Trisenox)FDA Link 02/2005
1	NF-kappa B (NF-kB)IBA 02/2005
1	Inositol (Myoinositol)IBA 10/2002

Therapy/Procedure

12	Therapeutics 01/2023 - 09/2009
1	Decompression 05/2022
1	TP protocol 12/2020
1	Combination Drug Therapy (Combination Chemotherapy) 03/2018